RAPID COMMUNICATION Animal Model Explains the Origins of the Cranial Dystonia Benign Essential Blepharospasm
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چکیده
Schicatano, Edward J., Michele A. Basso, and Craig Evinger. sensory-motor transformation in blink circuits following a Animal model explains the origins of the cranial dystonia benign subclinical basal ganglia dysfunction produces blepharoessential blepharospasm. J. Neurophysiol. 77: 2842–2846, 1997. spasm that exhibits many of the characteristics of BEB. The current study demonstrates that combining two mild alterations
منابع مشابه
Animal model explains the origins of the cranial dystonia benign essential blepharospasm.
The current study demonstrates that combining two mild alterations to the rat trigeminal reflex blink system reproduces the symptoms of benign essential blepharospasm, a cranial dystonia characterized by uncontrollable spasms of blinking. The first modification, a small striatal dopamine depletion, reduces the tonic inhibition of trigeminal reflex blink circuits. The second alteration, a slight...
متن کاملAnimal Models for Investigating Benign Essential Blepharospasm
The focal dystonia benign essential blepharospasm (BEB) affects as many as 40,000 individuals in the United States. This dystonia is characterized by trigeminal hyperexcitability, photophobia, and most disabling of the symptoms, involuntary spasms of lid closure that can produce functional blindness. Like many focal dystonias, BEB appears to develop from the interaction between a predisposing c...
متن کاملA Dynamic Circuit Hypothesis for the Pathogenesis of Blepharospasm
Blepharospasm (sometimes called "benign essential blepharospasm," BEB) is one of the most common focal dystonias. It involves involuntary eyelid spasms, eye closure, and increased blinking. Despite the success of botulinum toxin injections and, in some cases, pharmacologic or surgical interventions, BEB treatments are not completely efficacious and only symptomatic. We could develop principled ...
متن کاملThe metabolic topography of essential blepharospasm: a focal dystonia with general implications.
OBJECTIVE To determine the metabolic topography of essential blepharospasm (EB). BACKGROUND EB is a cranial dystonia of unknown etiology and anatomic localization. The authors have used 18F-fluorodeoxyglucose (FDG) and PET with network analysis to identify distinctive patterns of regional metabolic abnormality associated with idiopathic torsion dystonia (ITD), as well as sleep induction durin...
متن کاملIntractable Blepharospasm Treated with Bilateral Pallidal Deep Brain Stimulation
BACKGROUND Blepharospasm can be present as an isolated dystonia or in conjunction with other forms of cranial dystonia, causing significant disability. CASE REPORT We report a case of a 69-year-old male with craniocervical dystonia, manifesting primarily as incapacitating blepharospasm refractory to medical treatments. He underwent bilateral globus pallidus (GP) deep brain stimulation (DBS) w...
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تاریخ انتشار 1997